Job Description

Postdoctoral position in stem cell research
- Institute of Reproductive and Developmental Biology, Imperial College London, London, UK

Description: A postdoctoral position is available in the group of Dr Véronique Azuara (Epigenetics and Development group, Stem Cell Biology section) at the Institute of Reproductive and Developmental Biology, Imperial College London.

The group is studying the epigenetic mechanisms that define lineage potency of developing cells. We combine in vitro models of human and mouse embryo-derived stem cells (e.g. embryonic stem cells) with in vivo studies, to understand how pluripotency is acquired and maintained by a subset of cells and subsequently lost during mesoderm, endoderm or ectoderm lineage induction both in culture and in the embryo.

We are developing and using the timing of DNA replication across a panel of loci, as an indicator of chromatin state in a particular cell type. Previous studies exemplified how DNA replication profiles may provide a valuable ‘signature’ for cell identity and developmental stage. A postdoctoral scientist is now needed to further explore the dynamics of DNA replication and chromatin state in pluripotent cells and in cell fate commitment during early development.

Qualifications: Applicants should hold a PhD in a relevant field. A strong background in molecular and cell biology, biochemistry and/or cell imaging is required. Experience in embryogenesis and mouse development would be highly desirable.

Salary Details: The post is available from October 1st 2007 for a period of 2 years in the first instance. Salary range (£26-31k) is dependant on experience of the applicant.

Application Details: Enquiries and applications (including a summary of research experience, CV and name of three referees) should be directed to:

Dr Véronique Azuara
Imperial College London.
1st floor IRDB Building
Hammersmith Campus
Du Cane Road
London
W12 0NN
United Kingdom

Closing Date: Check with institute