Busslinger Lab Profile

Research Focus: Stem Cell Commitment in Hematopoiesis

Tissue-restricted stem cells give rise to different cell types of an organ by undergoing commitment to and subsequent differentiation along distinct lineages. By using a combination of mouse transgenic, cell biological and molecular approaches, we investigate the mechanisms by which transcription factors such as Pax5 control the commitment of early hematopoietic progenitors to the B cell lineage.