Skok Lab Profile

Research Focus: Nuclear organisation of immunoglobulin genes

B cell development takes place in the bone marrow where immunoglobulin(Ig) loci undergo a series of genetic modifications resulting in phenotypic and functional changes. Recombination of variable (V), diversity (D) and joining (J) regions gives rise to a diverse repertoire of functional B cell receptors, and allelic exclusion subsequently ensures monospecificity in terms of antigen recognition and, at a later stage, antibody secretion. Current research in my group is focused on identifying the factors involved in these processes and investigating their relationship with the initiation and propagation of changes that determine B cell identity.